LOT 200 "On Protein Synthesis." [In:] Symposia of the Society for Experimental Biology: The Biological Replication of Macromolecules. No 12, pp. 138-163. Cambridge: University Press, 1958. CRICK, FRANCIS. 1916-2004.
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CRICK, FRANCIS. 1916-2004.
"On Protein Synthesis." [In:] Symposia of the Society for Experimental Biology: The Biological Replication of Macromolecules. No 12, pp. 138-163. Cambridge: University Press, 1958. Large 8vo. Publisher's green cloth with printed dust jacket. A bit of soiling to top edge of leaves.WITH: First day of issue cover of 20 cent stamp Health Research, issued May 17, 1984, signed by Crick.GROUNDBREAKING PAPER WITH CRICK'S SIGNATURE. "Crick proposed two general principles: 1) The Sequence Hypothesis: 'The order of bases in a portion of DNA represents a code for the amino acid sequence of a specific protein. Each "word" in the code would name a specific amino acid. From the two dimensional genetic text, written in DNA, are forced the whole diversity of uniquely shaped three-dimensional proteins', and 2) The Central Dogma: 'Information transmitted from DNA and RNA to proteins, but information cannot flow from a protein to DNA" (Garrison-Morton 6895). These concepts are even more remarkable in the context of the scientific uncertainty of the time. "...as Crick pointed out, at the time, not everyone accepted that nucleic acids were involved in protein synthesis. In 1957, ribosomes were known only as microsomes ... messenger RNA was still undreamt of..." (Cobb, "60 years ago, Francis Crick changed the logic of biology." PLOS Biology, 2017).
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